The topic of gender affirmation is directly addressed in the podcast episodes, with one episode critically analyzing the practice of gender affirmation and its impact on gender non-conforming youth.

In Episode 13392, the episode 'examines new evidence challenging the medical transition of gender non-conforming youth, including a study showing most outgrow dysphoria, a UK report criticizing poor research standards, and leaked emails suggesting clinicians prioritize affirming transitions over fully informing children of risks.'

The other episode, Episode 43147, includes an interview with a speech therapist specializing in gender-affirming vocal coaching for transgender and gender non-conforming individuals, providing a different perspective on the topic of gender affirmation.