The podcast episodes provided cover various health challenges faced by the guests, including brain tumors, strokes, debilitating illnesses, and chronic conditions.

For example, in the episode "Mark Ruffalo", the actor shares the harrowing story of being diagnosed with a brain tumor at age 33 after having a dream about it. Similarly, in the episode Ella Mills: finding purpose and putting mental health first, Ella Mills discusses her experience with a debilitating health condition in her early 20s and how it shaped her journey.

Other episodes, such as Julia Gets Wise with Julie Andrews and Mother's Day Special with Bre's Mom, touch on the guests' experiences with health challenges and how they navigated them with resilience, faith, and support from loved ones.