The prefrontal cortex plays a crucial role in the podcast episodes, as it is extensively examined for its involvement in generating expectations, placebo/nocebo effects, and belief effects.

The prefrontal cortex's predictive capabilities and its influence on processes like neurotransmitter release, hormone levels, and physiological responses are examined in detail in "How Placebo Effects Work to Change Our Biology & Psychology".

Similarly, the role of the prefrontal cortex in self-narrative, emotional regulation, and the mechanisms behind a science-supported journaling protocol is a major focus in "A Science-Supported Journaling Protocol to Improve Mental & Physical Health".