The placebo effect describes how our expectations and mindsets can generate real biological changes, such as in neurotransmitter release, hormone levels, and physiological responses, through the prefrontal cortex's predictive capabilities.

This is the central focus of the "How Placebo Effects Work to Change Our Biology & Psychology" episode, which examines placebo effects, nocebo effects, and belief effects in detail.

The "Journal Club With Dr. Peter Attia | Metformin for Longevity & the Power of Belief Effects" episode also discusses belief effects, which are related to but distinct from placebo effects.