The podcast episodes discuss the use of psychedelic drugs, particularly in a medical or clinical setting, and their potential benefits for treating various mental health issues.

The episodes explore the history of psychedelic research, the current state of clinical trials, and the regulatory challenges surrounding the approval of psychedelic-assisted therapies.

Examples of specific episodes that cover this topic include Psychedelics' Long Strange Trip to the Doctor's Office, Audiobook: Steve Jobs by Walter Isaacson Episode 2, and Benjamin Breen on Margaret Mead, Psychedelics, and Utopia.