The concept of self-determination is a recurring theme throughout the provided podcast episodes, which cover a range of topics related to the struggles of various communities and nations to assert their autonomy and control over their own affairs.

Several episodes, such as the Strength & Solidarity episode on Mexico, the Code Switch episode on Ojibwe tribes, and the Srsly Wrong episode on Black anarchists, emphasize the importance of respecting the self-determination and collective power of marginalized communities, and not subordinating their agency or imposing external agendas.

Other episodes, such as the Revolutionary Left Radio episode on the Congolese struggle, the Eyes Left Podcast episode on Iran, and the TED Talks Daily episode on Ukraine, highlight the desire for self-determination and freedom from imperial oppression as a driving force behind various national liberation movements and struggles for democracy.

The podcast series as a whole demonstrates the wide-ranging and urgent relevance of the principle of self-determination in addressing issues of colonialism, imperialism, human rights, and the pursuit of justice and equality for marginalized peoples around the world.