The podcast episodes discuss various aspects of water contamination, including its impact on indigenous communities, environmental justice issues, and efforts to address the problem.

For example, in the episode Near The Water, a Diné hydrologist discusses water contamination from mining activities on indigenous lands, and the need for community-driven research and solutions. The episode Tracy E. Perkins, "Evolution of a Movement: Four Decades of California Environmental Justice Activism" explores how environmental justice activists in California have fought against the contamination of drinking water supplies.

In the episode EP 61: Bringing Water Equity to America, the director of Water Equity and Climate Resilience discusses the challenges of water contamination and affordability that disproportionately affect communities of color, while the episode Ep. 98: Reviving the Gulf Coast Dead Zone examines the issue of agricultural runoff and its impact on water pollution.