The podcast episodes delve into the latest scientific research on memory, examining how memories are formed, consolidated, and potentially manipulated.

Several episodes, such as 1004: Memory | Skeptical Sunday, 1002: Charan Ranganath | The Mysteries of Memory and Why We Remember, and Memory and Forgetting, discuss the neuroscientific principles underlying memory formation, the role of brain regions like the hippocampus, and the ethical implications of being able to artificially alter memories.

The episodes also explore related topics like the unreliability of eyewitness testimony, the impact of emotions and attention on memory, and techniques for improving everyday memory.