The podcast episodes cover the topic of medication in the context of mental health, highlighting how individuals have used prescription drugs to address issues such as anxiety, depression, and other conditions.

For example, in the episode 'Anxiety: From Hospitals to Healing [RE-RUN]', the host Alix discusses her personal experience with taking the medication Lexapro to treat her anxiety, sharing her initial reluctance and the medication's effectiveness.

Similarly, in the episode 'Call It PMS', Camilla Luddington discusses her experience with taking Zoloft for her mental health, while in the episode 'Embracing the Power of 'No': Sheryl Green's Insights on Boundaries and Self-Care | Season 3 Episode 3', Cheryl shares her experience of taking antidepressants for a chemical imbalance.

The episodes also explore the role of medication in the broader context of mental health treatment, with discussions around the use of various drugs, including SSRIs, SNRIs, and benzodiazepines, as well as the importance of considering the lowest effective dose and the potential for side effects.